A network pharmacology approach to explore Dahuang on colon cancer

To investigate the mechanism of action Rhubarb (Dahuang) in treatment colon cancer by network pharmacological method. TCMSP database was used to screen active components and targets Rhubarb, Genecards relevant cancer, Venny 2.1.0 software make intersection potential for were obtained.Cytoscape 3.7.2 STRING construct component-target related targets. The important obtained analyzing network, GO KEGG pathway enrichment analysis performed on them using Metascape database. Sixty ingredients including EUPATIN, Mutatochrome, Physciondiglucoside, Procyanidin B-5,3’ -o-gallate, rhin screened from which could act 61 targets.Among them, 13 targets, PTGS2, IL1B Bax, are may be involved various biological processes such as response regulation nutritional level, homeostasis multicellular organisms peptide secretion through PI3K other pathways. can participate multi-target multi-pathway.